Position Title: Scientist
Work Location: Pleasanton, CA, 94588 
Assignment Duration: 12 Months
Work Arrangement: Onsite

Position Summary:
Pathology Biology & Integrated Analytics group (Pleasanton, CA) at The Organization is seeking a highly motivated Scientist for molecular cloning, cell culture, FPLC purification and antibody engineering and characterization. The qualified candidate will join a team of scientists focused on monoclonal antibody development for IVD and CDx assays.

Key Responsibilities:

• Plans and/or manages smaller, less complex local projects (e.g. with moderate project management complexity, problem definition, and/or short to medium term implications).
• Participates in project teams across the R&D department and functional groups.
• Can represent the Team Lead in project teams in his/her absence on instruction.
• Ensures that quality standards are met and plans and coordinates the performance of tasks largely independently.
• Is aware of new developments in the field and refers to the possible use of these in diagnostics.
• Contributes to collaboration and close networking within the departments as part of R&D projects.
• Analyzes and interprets the R&D results largely independently and presents them to the relevant committees within their own function.
• Uses specified strategies to resolve problems and acts within defined guidelines.

Qualification & Experience:

• Experience and in-depth knowledge in monoclonal antibody development and antibody engineering.
• Proficiency in standard cloning techniques (e.g., PCR, restriction/ligation, Gibson assembly) for subcloning antibody sequences into mammalian expression vectors.
• Familiarity with antibody sequences and sequence analysis software.
• Significant experience with transient protein expression in mammalian cell culture systems (e.g., HEK293, CHO).
• Experience with antibody purification and characterization (eg. FPLC purification, HPLC, ELISA, SDS-PAGE, WB, IHC).
• Domain knowledge in oncology, immunology, or protein chemistry.

Is a Plus:

• Practical experience using computational tools (e.g., PyMOL, VMD) for structure-based analysis of antibodies.
• Ability to interpret structural data (PDB files) and relate it directly to experimental outcomes (e.g., binding, stability).
• Knowledge of biophysical characterization techniques (eg. DSC, DLS) to assess protein structural integrity and stability.
• Experience with computational protein engineering and antibody epitope modeling.
• Experience with advanced protein modifications analysis and their impact on function.
• Familiarity with formulation and stability studies for final antibody products.

 
 
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position’s starting pay is: $ 60.00/hr.