Scientist I
Spectraforce
Cambridge, Massachusetts
3 days ago
Job Description
Job Title: Scientist I
Duration: 8 Months
Location: Cambridge, MA 02141
HM Notes:
Nice to have:
Description:
We are looking for a highly motivated scientist to join our structural biology and biophysics group in Cambridge MA. As a key member of our dynamic team, you will be responsible for determining critical structural biology data through both cryo-electron microscopy and x-ray crystallography; actively pursuing solutions for unmet medical needs in diverse therapeutic areas and collaborating with multidisciplinary teams within Cambridge, US, Frankfurt, Germany and Paris, France. The successful candidate will excel in a fast-paced, highly diverse discovery environment, will have a strong focus on scientific rigor, have proven success in organized and independent work, and an exceptional attention to detail. Applicants who are passionate about structural biology are encouraged to apply.
Candidate profile:
• X-ray and CryoEM expert scientist that can independently design and carry out x-ray, EM experiments and interpret results (sample preparation, data collection, data processing and solving structures). Analyze interactions and propose structure-based improvements for small-molecule drug discovery. Enable building state-of-the art technologies in related areas to enhance research activities.
• Expertise with all related softwares (CryoSparc, SerialEM, Relion, cisTEM, Chimera, Eman2, Coot, phenix, ccp4 suite etc.).
• Provide expertise to project teams pursuing different drug modalities.
• Manage and deliver on projects in a timely fashion.
• Experience in biophysical characterization (SPR, DSF, MST etc.) is a plus.
• Have excellent communication skills. Should be able to clearly articulate data, project strategies both internally and externally.
Responsibilities / Duties
• Determine structural biology data using cryo-electron microscopy (Cryo-EM) and X-ray crystallography.
• Design and conduct experiments independently for structure determination, including:
o Sample preparation
o Data collection
o Data processing
o Structure solving
• Analyze molecular interactions and propose structure-based optimizations to support small-molecule drug discovery.
• Provide scientific expertise to project teams working on different drug modalities.
Qualifications:
PhD with 1+yrs of postdoctoral and/or industry experience in Structural Biology, Biophysics, Protein Biochemistry or related discipline. Strong experience in cryo-EM and x-ray crystallography is required. The ideal candidate should be detail-oriented, organized and demonstrate good lab practices. Must be a collaborative team player with strong communication skills.
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position’s starting pay is: $ 55.00/hr.
Duration: 8 Months
Location: Cambridge, MA 02141
| 1st | ||
|---|---|---|---|
| Mon-Fri 8AM-4PM |
HM Notes:
- Fully onsite position
- Open to candidates willing to relocate at their own expense
- Paid parking required at this worksite
- Team is about 7 team members
- May work in temp-controlled environments
- PHD Degree
- Years of experience 0-3 years
- Willing to consider candidates with 0 years industry, if in school experience in Structural Biology, Biophysics, Protein Biochemistry or related discipline
- Familiarity with related softwares: (CryoSparc, SerialEM, Relion, cisTEM, Chimera, Eman2, Coot, phenix, ccp4 suite etc.) - all are not required, however a combination of those listed
- Collaborative team player with strong communication skills.
Nice to have:
- Experience in biophysical characterization (SPR, DSF, MST etc.) is a plus.
Description:
We are looking for a highly motivated scientist to join our structural biology and biophysics group in Cambridge MA. As a key member of our dynamic team, you will be responsible for determining critical structural biology data through both cryo-electron microscopy and x-ray crystallography; actively pursuing solutions for unmet medical needs in diverse therapeutic areas and collaborating with multidisciplinary teams within Cambridge, US, Frankfurt, Germany and Paris, France. The successful candidate will excel in a fast-paced, highly diverse discovery environment, will have a strong focus on scientific rigor, have proven success in organized and independent work, and an exceptional attention to detail. Applicants who are passionate about structural biology are encouraged to apply.
Candidate profile:
• X-ray and CryoEM expert scientist that can independently design and carry out x-ray, EM experiments and interpret results (sample preparation, data collection, data processing and solving structures). Analyze interactions and propose structure-based improvements for small-molecule drug discovery. Enable building state-of-the art technologies in related areas to enhance research activities.
• Expertise with all related softwares (CryoSparc, SerialEM, Relion, cisTEM, Chimera, Eman2, Coot, phenix, ccp4 suite etc.).
• Provide expertise to project teams pursuing different drug modalities.
• Manage and deliver on projects in a timely fashion.
• Experience in biophysical characterization (SPR, DSF, MST etc.) is a plus.
• Have excellent communication skills. Should be able to clearly articulate data, project strategies both internally and externally.
Responsibilities / Duties
• Determine structural biology data using cryo-electron microscopy (Cryo-EM) and X-ray crystallography.
• Design and conduct experiments independently for structure determination, including:
o Sample preparation
o Data collection
o Data processing
o Structure solving
• Analyze molecular interactions and propose structure-based optimizations to support small-molecule drug discovery.
• Provide scientific expertise to project teams working on different drug modalities.
Qualifications:
PhD with 1+yrs of postdoctoral and/or industry experience in Structural Biology, Biophysics, Protein Biochemistry or related discipline. Strong experience in cryo-EM and x-ray crystallography is required. The ideal candidate should be detail-oriented, organized and demonstrate good lab practices. Must be a collaborative team player with strong communication skills.
Applicant Notices & Disclaimers
- For information on benefits, equal opportunity employment, and location-specific applicant notices, click here
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position’s starting pay is: $ 55.00/hr.