Job Title: Scientist Location: South San Francisco, CA 94080 Duration: 12 months Onsite - Standard Hours - Mon - Friday
Description: Ideal: PHD is preferred or exceptional working experience with a MS. Review top 3 skillsets for technical skills.
Most important: The Client is seeking a talented and motivated individual with expertise in enzymology and biochemical & biophysical assay development to join the Bioassay & Profiling group to support small molecule drug discovery programs within the Discovery Technologies department in our South San Francisco research site. The successful candidate should possess strong technical expertise & exceptional hands-on laboratory skills, have excellent written and oral communication skills, enjoy working in a fast-paced multi-functional team environment, and keep current with field of expertise, including literature and technology development.
Preferred Qualifications • PhD in biophysics, biochemistry, molecular biology, or a related discipline. • Expertise in enzymology, ligand binding kinetics, and mechanism-of-action studies. • A deep and broad understanding of the development, validation & execution of a wide array of binding & functional activity-based assays such as AlphaScreen, TR-FRET, FP, etc. • Experience with biophysical techniques and instruments used to characterize ligand binding such as Microscale Thermophoresis (MST), Differential Scanning Fluorimetry (DSF), Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), etc. • Experience with microplate readers such as PerkinElmer Envision and automated liquid handling systems including Multidrop, acoustic dispensers, and digital dispensers. • Expertise in handling, analyzing and visualizing assay data sets and proficient in software platform such as GraphPad Prism. • Drug discovery research experience in diverse target classes is a plus but not required. • Detail-oriented and analytical with excellent problem-solving skills. • Excellent organizational, interpersonal and communication skills, along with the ability to work in a flexible team-oriented environment.
Top 3 Must Have Skill Sets: • A deep and broad understanding of the development, validation & execution of a wide array of binding & functional activity-based assays such as AlphaScreen, TR-FRET, FP, etc. • Experience with biophysical techniques and instruments used to characterize ligand binding such as Microscale Thermophoresis (MST), Differential Scanning Fluorimetry (DSF), Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), etc. • Excellent organizational, interpersonal and communication skills, along with the ability to work in a flexible team-oriented environment.
Day to Day Responsibilities: • Contribute to the assay strategies and apply a variety of scientific principles and concepts to the assay design, assay development and troubleshooting in support of small molecule drug discovery. • Develop and execute biochemical assays and convert into high-throughput screening (HTS) format to enable HTS campaign and meet project goals. • Apply sophisticated biochemical and biophysical assay techniques to develop and perform potency, kinetic and mechanistic assays for hits validation, compound-target engagement, and SAR study. • Advance biochemical/biophysical assay screening capabilities and evaluate new assay technologies and experimental approaches using scientific theory and technical literature. • Strong data analysis cababilities and able to communicate and present research results and provide scientific and technical support. • Collaborate with internal cross-functional teams and external partners to enable project progression.
About Us: Established in 2004, SPECTRAFORCE® is one of the largest and fastest-growing diversity-owned staffing firms in the US. The growth of our company is a direct result of our global client service delivery model that is powered by our state-of-the-art A.I. proprietary talent acquisition platform, robust ISO 9001:2015/ISO 27001 certified processes, and strong and passionate client engaged teams. We have built our business by providing talent and project-based solutions, including Contingent, Permanent, and Statement of Work (SOW) services to over 140 clients in the US, Canada, Puerto Rico, Costa Rica, and India. Key industries that we service include Technology, Financial Services, Life Sciences, Healthcare, Telecom, Retail, Utilities and Transportation. SPECTRAFORCE is built on a concept of “human connection,” defined by our branding attitude of NEWJOBPHORIA®, which is the excitement of bringing joy and freedom to the work lifestyle so our people and clients can reach their highest potential. Learn more at: http://www.spectraforce.com
Benefits: SPECTRAFORCE offers ACA compliant health benefits as well as dental, vision, accident, critical illness, voluntary life, and hospital indemnity insurances to eligible employees. Additional benefits offered to eligible employees include commuter benefits, 401K plan with matching, and a referral bonus program. SPECTRAFORCE provides unpaid leave as well as paid sick leave when required by law.
Equal Opportunity Employer: SPECTRAFORCE is an equal opportunity employer and does not discriminate against any employee or applicant for employment because of race, religion, color, sex, national origin, age, sexual orientation, gender identity, genetic information, disability or veteran status, or any other category protected by applicable federal, state, or local laws. Please contact Human Resources at LOA@spectraforce.com if you require reasonable accommodation.
California Applicant Notice: SPECTRAFORCE is committed to complying with the California Privacy Rights Act (“CPRA”) effective January 1, 2023; and all data privacy laws in the jurisdictions in which it recruits and hires employees. A Notice to California Job Applicants Regarding the Collection of Personal Information can be located on our website. Applicants with disabilities may access this notice in an alternative format by contacting NAHR@spectraforce.com.
LA County, CA Applicant Notice: If you are selected for this position with SPECTRAFORCE, your offer is contingent upon the satisfactory completion of several requirements, including but not limited to, a criminal background check. We consider qualified applicants with arrest or conviction records for employment in accordance with all local ordinances and state laws, including the Los Angeles County Fair Chance Ordinance for Employers (FCO) and the California Fair Chance Act (FCA). The background check assessment will consider whether a criminal history could reasonably have a direct, adverse impact on the job-related safety, security, trust, regulatory compliance, or suitability for this role. Such findings may result in withdrawal of a conditional job offer.
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position’s starting pay is: $42.02/hr.
