Title: Scientist III, Computational Pathology Location: Can be Hybrid or remote in South San Francisco, CA Duration: 1 year (possibility of extension)
Purpose: The Precision Medicine Pathology team drives the scientific strategy for translational tissue-based biomarker development & discovery target validation/MOA projects, leads pathology collaborative programs, conducts histopathological evaluation & analysis of IHC & spatial biology technologies, and provides technical/scientific leadership to histotechnicians & pathology scientists. The successful candidate will have advanced knowledge and experience analyzing spatial transcriptomics and proteomics data generated on the CosMx SMI and PhenoCycler Fusion platforms.
Responsibilities: • Implementation of different scripts and pipelines for spatial transcriptomics data analysis and analysis of high-plex PhenoCycler Fusion (CODEX) images. • Independently performing end-to-end high-plex image analysis (tissue classification, cell segmentation, detection of marker positivity, cell phenotyping, unsupervised clustering, neighborhood analysis, proximity analysis). • Acting as a subject matter resource and training other team members in spatial analysis tasks. • Collaborating with pathologists and digital pathology scientists to support spatial biology projects. • Presenting the results and findings from spatial biology studies to stakeholders.
Qualifications: • MSc, PhD, or equivalent degree in biological sciences / computational biology / engineering / computer science / informatics • Fluency in Python and R • Experience in implementing and utilizing open-source scripts and pipelines for high-plex image analysis • Experience in quantitative digital pathology analysis platforms such as Halo, Visiopharm, QuPath • Close familiarity with tissue microscopic anatomy and histology (normal and diseased) is a plus • Excellent verbal communication skills are required including the demonstrated ability to effectively and clearly summarize results for presentation and report generation • Strong motivation, attention to detail, ability to think independently and fully integrate into a high achieving team environment • Ability to multi-task and manage multiple projects.
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At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position’s starting pay is: $ 70.00/hr.
