Job title: Scientist I Location: Cambridge, MA (02141) Duration: 12 Months
Work Schedule
9-5 EST
HM Notes:
Open to candidates willing to relocate at their own expense.
Paid parking required, Fully onsite role
Candidates who have previous Principal level Scientist experience may be considered overqualified, as this is a level I role.
Must Have: • PhD in Chemistry, Biology, Biological Engineering, or a related field • 1 year of professional work experience (in biotech or pharma) • Protein and antibody engineering workflows, including primary sequence design, expression, purification, characterization • Bioconjugate chemistry, also referred to as: antibody conjugate experience ADJ • Strong analytical bio chem skills • SDS page, chromatography, HPLC Preferred Skills: • Previous experience with: (liquid handler, automated buffers) – biochemical assays (nice to have) Computational skills • Computational and AI/ML approaches for rational protein engineering, including AI 3D structure prediction, homology modeling, antibody/antigen docking, other relevant experience • L&P Experience
Description: Seeking a highly motivated Scientist I or Scientist II to join the Non-Viral Gene Therapy (NVGT) Team. The successful candidate will have hands-on experience in antibody and protein engineering, with a focus on bioconjugation chemistry. The candidate will work closely with the LNP formulation team to achieve extrahepatic delivery of LNPs.
Responsibilities: • Execute protein conjugation reactions for both screening efforts and developability to enable nanoparticle targeting to specific cells and/or tissues. • Perform downstream analytical assays such as SDS-PAGE, SEC-HPLC, RP-HPLC, BLI, DSF, CE-SDS and/or flow-cytometry. • Perform incorporation of targeting antibody into LNPs and execute associated analytical assays, including DLS, zeta potential, nucleic acid content, endotoxin • Design protein and antibody molecules at the primary sequence level • Support management of CRO for molecule production • Closely work with therapeutic area biologists and project teams to design functional experiments and interpret data • Execute and carefully document experiments using electronic laboratory notebook system and clearly communicate results to team members. • Plan, execute, and record experiments as guided in a time sensitive manner. • Assume responsibility for critical reagent sourcing and maintain adequate supply and inventory. • Author standard operating procedures, study plans and reports and present findings. • Foster creativity, productivity, execution with a sense of urgency, scientific integrity and accountability. Maintains a collaborative culture.
Requirements: • PhD in Chemistry, Biology, Biological Engineering, or a related field with a minimum of 1-3 years of relevant industry experience. • Strong experience with protein and antibody engineering workflows, including primary sequence design, expression, purification, characterization • Direct experience with site-specific bioconjugate chemistry • Strong analytical biochemistry experience for protein and antibody engineering • Proficient in performing structure-function analysis and bioinformatic analysis of antibodies, antigens, and other proteins • Experience with automation and high throughput platform(s) • Experience with Biolayer Interferometry or equivalent technique • Preferred use of computational and AI/ML approaches for rational protein engineering, including AI 3D structure prediction, homology modeling, antibody/antigen docking, other relevant experience • Preferred familiarity with formulation and analysis of lipid nanoparticles for research use • Outstanding written and oral communication skills along with the ability to work collaboratively in a team setting. • Demonstrated knowledge and skills in solving scientific problems, ability to troubleshoot, and willingness to learn. • Demonstrated ability to independently design, execute, interpret, and present experimental results. • Flexibility to adapt to rapidly changing priorities and deadlines in a dynamic, fast paced industry and work environment.
About Us: Established in 2004, SPECTRAFORCE® is one of the largest and fastest-growing diversity-owned staffing firms in the US. The growth of our company is a direct result of our global client service delivery model that is powered by our state-of-the-art A.I. proprietary talent acquisition platform, robust ISO 9001:2015/ISO 27001 certified processes, and strong and passionate client engaged teams. We have built our business by providing talent and project-based solutions, including Contingent, Permanent, and Statement of Work (SOW) services to over 140 clients in the US, Canada, Puerto Rico, Costa Rica, and India. Key industries that we service include Technology, Financial Services, Life Sciences, Healthcare, Telecom, Retail, Utilities and Transportation. SPECTRAFORCE is built on a concept of “human connection,” defined by our branding attitude of NEWJOBPHORIA®, which is the excitement of bringing joy and freedom to the work lifestyle so our people and clients can reach their highest potential. Learn more at: http://www.spectraforce.com
Benefits: SPECTRAFORCE offers ACA compliant health benefits as well as dental, vision, accident, critical illness, voluntary life, and hospital indemnity insurances to eligible employees. Additional benefits offered to eligible employees include commuter benefits, 401K plan with matching, and a referral bonus program. SPECTRAFORCE provides unpaid leave as well as paid sick leave when required by law.
Equal Opportunity Employer: SPECTRAFORCE is an equal opportunity employer and does not discriminate against any employee or applicant for employment because of race, religion, color, sex, national origin, age, sexual orientation, gender identity, genetic information, disability or veteran status, or any other category protected by applicable federal, state, or local laws. Please contact Human Resources at LOA@spectraforce.com if you require reasonable accommodation.
California Applicant Notice: SPECTRAFORCE is committed to complying with the California Privacy Rights Act (“CPRA”) effective January 1, 2023; and all data privacy laws in the jurisdictions in which it recruits and hires employees. A Notice to California Job Applicants Regarding the Collection of Personal Information can be located on our website. Applicants with disabilities may access this notice in an alternative format by contacting NAHR@spectraforce.com.
LA County, CA Applicant Notice: If you are selected for this position with SPECTRAFORCE, your offer is contingent upon the satisfactory completion of several requirements, including but not limited to, a criminal background check. We consider qualified applicants with arrest or conviction records for employment in accordance with all local ordinances and state laws, including the Los Angeles County Fair Chance Ordinance for Employers (FCO) and the California Fair Chance Act (FCA). The background check assessment will consider whether a criminal history could reasonably have a direct, adverse impact on the job-related safety, security, trust, regulatory compliance, or suitability for this role. Such findings may result in withdrawal of a conditional job offer.
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position’s starting pay is: $54.00/hr.
