Job Title: Research Scientist Location: San Diego, CA*Onsite Duration: 12 Months
Top Skills: - Purification and characterization of bispecific antibodies - Experience with complex modalities - Automated liquid handling experience a plus
We are seeking a talented and self-motivated individual with a B.S. in biology, biochemistry or applicable sciences +5 years of academic/industry experience or Master‘s Degree and 3+ years of academic/industry experience or PhD in biochemistry, who is interested in joining the Protein Production and Quality Attributes team within Discovery Biotherapeutics in San Diego. The successful candidate will have knowledge in purification and characterization of bispecific antibodies and will be familiar with state-of-the-art methods to support biotherapeutic discovery efforts.
The candidate will have demonstrated success in purification of antibodies and complex molecules, executing challenging multi-step purification, analytical data interpretation, troubleshooting and formulation of final product. Experience in automation of high-throughput purification is a plus.
The candidate will show an independent ability to design purification methods, understand biochemical concepts and interpret data to generate and improve design. Candidate should have excellent communication skills and a collaborative style. Candidate will be expected to participate in team meetings and provide expertise to support discovery programs.
CORE JOB FUNCTIONS: Primary responsibility is to perform original research to develop marketable products. Special emphasis will be placed on automated antibody and bispecific purification, which will involve working with GE AKTA (Pure/Avant) and Unicorn software. Knowledge of Protein Maker instrument a plus. Generate mg to gram quantities of material for in-vivo efficacy studies. Develop and optimize high-throughput purification capabilities using Lynx900 and KingFisher Flex System. Packing of chromatography columns, operating endotoxin free chromatography, including operating preparative (FPLC) and analytical (HPLC) chromatography systems. Analytical characterization including endotoxin measurements, protein quantitation assays, analytical HPLC chromatography (HIC, SEC), capillary electrophoresis (CE-SDS and cIEF), DLS, and mass photometry. Buffer preparation, molar concentration quantitation and pH adjustment. Storing, inventorying, and ordering department supplies. Participates on cross-functional teams by performing assigned experiments and offering technical advice at team meetings; shares technical expertise with other colleagues; trains or provides guidance to other personnel, if needed. Maintain a neat and clean work environment. Manage your workload with minimal supervision. Collaborate and communicate with cross-functional teams.
BASIC QUALIFICATION: Bachelor's Degree 5+ years of academic / industry experience Or Master's Degree 3+ years of academic / industry experience Or PhD No experience required
PREFERRED QUALIFICATIONS: Bachelor's Degree 5+ years or Master's Degree 3+ years or PhD with no experience in Biochemistry, Molecular Biology, Bioengineering, Cell biology or related discipline. Experience in antibody/bi-specific purification and characterization including, but not limited to SDS-PAGE, CE-SDS, CiEF, AnSEC, endotoxin measurement, A280. Automated liquid handling a plus. Sample inventory management. Exceptional organizational skills and attention to detail. Excellent time management skills and multi-tasking capabilities. Must be very detail-oriented and organized, with excellent time-management and multitasking skills. Have outstanding analytic and problem-solving abilities. Display excellent verbal and written communication, interpersonal and presentation skills, as well as the ability to interact tactfully and effectively with employees at all levels of the organizational structure. Must be highly self-motivated, detail-oriented, well organized and work effectively as part of a team. Demonstrate a track record of initiative, creativity, organization, and independent performance at a high level combined with attention to detail and adherence to timelines/deliverables, and documentation.
About Us: Established in 2004, SPECTRAFORCE® is one of the largest and fastest-growing diversity-owned staffing firms in the US. The growth of our company is a direct result of our global client service delivery model that is powered by our state-of-the-art A.I. proprietary talent acquisition platform, robust ISO 9001:2015/ISO 27001 certified processes, and strong and passionate client engaged teams. We have built our business by providing talent and project-based solutions, including Contingent, Permanent, and Statement of Work (SOW) services to over 140 clients in the US, Canada, Puerto Rico, Costa Rica, and India. Key industries that we service include Technology, Financial Services, Life Sciences, Healthcare, Telecom, Retail, Utilities and Transportation. SPECTRAFORCE is built on a concept of “human connection,” defined by our branding attitude of NEWJOBPHORIA®, which is the excitement of bringing joy and freedom to the work lifestyle so our people and clients can reach their highest potential. Learn more at: http://www.spectraforce.com
Benefits: SPECTRAFORCE offers ACA compliant health benefits as well as dental, vision, accident, critical illness, voluntary life, and hospital indemnity insurances to eligible employees. Additional benefits offered to eligible employees include commuter benefits, 401K plan with matching, and a referral bonus program. SPECTRAFORCE provides unpaid leave as well as paid sick leave when required by law.
Equal Opportunity Employer: SPECTRAFORCE is an equal opportunity employer and does not discriminate against any employee or applicant for employment because of race, religion, color, sex, national origin, age, sexual orientation, gender identity, genetic information, disability or veteran status, or any other category protected by applicable federal, state, or local laws. Please contact Human Resources at LOA@spectraforce.com if you require reasonable accommodation.
California Applicant Notice: SPECTRAFORCE is committed to complying with the California Privacy Rights Act (“CPRA”) effective January 1, 2023; and all data privacy laws in the jurisdictions in which it recruits and hires employees. A Notice to California Job Applicants Regarding the Collection of Personal Information can be located on our website. Applicants with disabilities may access this notice in an alternative format by contacting NAHR@spectraforce.com.
LA County, CA Applicant Notice: If you are selected for this position with SPECTRAFORCE, your offer is contingent upon the satisfactory completion of several requirements, including but not limited to, a criminal background check. We consider qualified applicants with arrest or conviction records for employment in accordance with all local ordinances and state laws, including the Los Angeles County Fair Chance Ordinance for Employers (FCO) and the California Fair Chance Act (FCA). The background check assessment will consider whether a criminal history could reasonably have a direct, adverse impact on the job-related safety, security, trust, regulatory compliance, or suitability for this role. Such findings may result in withdrawal of a conditional job offer.
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position’s starting pay is: $55.00/hr.
