Title: Oligonucleotide Scientist II Duration: 4+ Months Location: South San Francisco, CA 94080
The Position: We are seeking a creative, self-motivated, collaborative Contractor/Scientist-II to join the Department of Protein Chemistry (PC) – Protein Sciences (PS). We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group. Experience in delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred. The successful candidate will join an interdisciplinary chemistry team working in RNAi biology research and will contribute positively to its developing culture.
Key Responsibilities:
The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology and oncology, to help build a comprehensive therapeutic discovery strategy.
Good understanding and also troubleshooting experience in oligonucleotide synthesis, impurity profiling is a plus.
Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC and desalting units.
Perform literature reviews, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression.
Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
Maintaining a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.
Requirements:
The candidate must have hands-on experience in oligonucleotide synthesis using automated oligo synthesizers, novel nucleic acid chemistry, oligonucleotide purification and characterization using HPLC and mass spectrometry.
The qualified individual will possess a BS/MS in Organic Chemistry or related discipline.
The pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics is preferred.
A good understanding of nucleic acid therapeutic modalities, modification chemistries, sequence selection, and mechanism of action is preferred.
Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or bio-conjugation is desirable.
Good communication and interpersonal skills are essential and will be evaluated during the interview process.
The ideal candidate should be highly motivated and have strong problem-solving, analytical, communication and organizational skills.
CPRA: The Company is committed to complying with the California Privacy Rights Act (“CPRA”) effective January 1, 2023; and all data privacy laws in the jurisdictions in which it recruits and hires employees. A Notice to California Job Applicants Regarding the Collection of Personal Information can be located on our website. Applicants with disabilities may access this notice in an alternative format by contacting NAhr@spectraforce.com.
About Us: Established in 2004, SPECTRAFORCE® is one of the largest and fastest-growing diversity-owned staffing firms in the US. The growth of our company is a direct result of our global client service delivery model that is powered by our state-of-the-art A.I. proprietary talent acquisition platform, robust ISO 9001:2015/ISO 27001 certified processes, and strong and passionate client engaged teams. We have built our business by providing talent and project-based solutions, including Contingent, Permanent, and Statement of Work (SOW) services to over 140 clients in the US, Canada, Puerto Rico, Costa Rica, and India. Key industries that we service include Technology, Financial Services, Life Sciences, Healthcare, Telecom, Retail, Utilities and Transportation. SPECTRAFORCE is built on a concept of “human connection,” defined by our branding attitude of NEWJOBPHORIA®, which is the excitement of bringing joy and freedom to the work lifestyle so our people and clients can reach their highest potential. Learn more at: http://www.spectraforce.com
Benefits: SPECTRAFORCE offers ACA compliant health benefits as well as dental, vision, accident, critical illness, voluntary life, and hospital indemnity insurances to eligible employees. Additional benefits offered to eligible employees include commuter benefits, 401K plan with matching, and a referral bonus program. SPECTRAFORCE provides unpaid leave as well as paid sick leave when required by law.
Equal Opportunity Employer: SPECTRAFORCE is an equal opportunity employer and does not discriminate against any employee or applicant for employment because of race, religion, color, sex, national origin, age, sexual orientation, gender identity, genetic information, disability or veteran status, or any other category protected by applicable federal, state, or local laws. Please contact Human Resources at LOA@spectraforce.com if you require reasonable accommodation.
California Applicant Notice: SPECTRAFORCE is committed to complying with the California Privacy Rights Act (“CPRA”) effective January 1, 2023; and all data privacy laws in the jurisdictions in which it recruits and hires employees. A Notice to California Job Applicants Regarding the Collection of Personal Information can be located on our website. Applicants with disabilities may access this notice in an alternative format by contacting NAHR@spectraforce.com.
LA County, CA Applicant Notice: If you are selected for this position with SPECTRAFORCE, your offer is contingent upon the satisfactory completion of several requirements, including but not limited to, a criminal background check. We consider qualified applicants with arrest or conviction records for employment in accordance with all local ordinances and state laws, including the Los Angeles County Fair Chance Ordinance for Employers (FCO) and the California Fair Chance Act (FCA). The background check assessment will consider whether a criminal history could reasonably have a direct, adverse impact on the job-related safety, security, trust, regulatory compliance, or suitability for this role. Such findings may result in withdrawal of a conditional job offer.
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position’s starting pay is: $31.00/hr.
