Bio Analytical Scientist

Spectraforce

Seattle, Washington


a month ago

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Bio Analytical Scientist
Spectraforce
Seattle, Washington

a month ago

Job Description

Job Title: Bio Analytical Scientist
Location: Seattle, WA, 98101*Onsite
Duration: 12 Months

Top Skills:

• Proven experience with physicochemical analytical techniques such as chromatography, electrophoresis/CE, etc.
experience working with Waters UPLC system and Empower software
• Methods: SEC-U/HPLC, SEC-MALS, IEX, RP-LC, Affinity, CE: PA800 (SCIEX) CE-SDS, CZE, cIEF
• Experience with proteins characterization preferred

Position Summary:
Cell Therapy Product and Analytical Development (P&AD) is seeking an enthusiastic, self-driven Scientist to join its Residual, Ancillary Materials and Protein Characterization analytical development team. The Scientist will lead development of analytical methods to characterize process-related impurities and assess impurity clearance in autologous and allogenic cell therapies. The Scientist will be responsible for developing impactful methods, including QC methods for lot release testing as well as characterization methods that support process development and comparability assessments. These methods will be used to further our understanding of cell therapies, and support development of manufacturing processes, and/or QC release of the drug product. The successful candidate must have extensive hands-on experience in assay development and possess excellent communication skills in order to work on projects requiring close collaboration with other groups, such as discovery research, product sciences, process development, and QC. Additionally, the Scientist will interface with external vendors (e.g., CMO’s) for the successful management of any transferred analytical methods. The Scientist should be passionate about developing novel medicines, thrive in an intellectually challenging environment, and enjoy collaborating with a team of likeminded Scientists.

**Roles and Responsibilities**
• Serve as a subject matter expert responsible for developing robust analytical methods and expanding product and process understanding.
• Independently develop and execute bioanalytical or molecular assays (e.g. chromatography, electrophoresis/CE assays)
• Identify issues, lead troubleshooting experiments, and determine solutions with minimal to no guidance
• Train users on method execution, data analyses, and proper use of instrumentation
• Lead qualification and transfer of analytical methods to external stakeholders
• Routinely present work at team, technical team, and department meetings
• Maintain meticulous laboratory notebooks
• Analyzing, interpreting, and presenting data to internal and external stakeholders (Power Point Presentations)
• Author, review and approve technical documents, including methods, protocols, reports, and SOPs
• Deliver lifecycle-managed analytical methods for multiple programs with an understanding of ICH/FDA/EMEA best practices and current thinking.
• Facilitate smooth operation of the laboratory, including ordering, assisting in the cryopreservation of cellular material, sample management, etc.

**Qualifications & Experience**
Education:
• BS, MS or PhD in Molecular Biology, Analytical Biochemistry, Immunology, Microbiology, Cell Biology, or related field. PhD with 0-3 years, or MS with 3+ years, or BS with 7+ years of relevant industry experience.
Basic Qualifications
• Proven experience with physicochemical analytical techniques such as chromatography, electrophoresis/CE, etc.
experience working with Waters UPLC system and Empower software
• Methods: SEC-U/HPLC, SEC-MALS, IEX, RP-LC, Affinity, CE: PA800 (SCIEX) CE-SDS, CZE, cIEF
• Experience with proteins characterization preferred
• Strong problem-solving ability to troubleshoot complex technical and scientific problems.
• Experience with writing technical and regulatory documents for interdepartmental use and external vendors (e.g., CMO’s).
• Strong attention to detail.
• Outstanding written and oral communication skills.
• Work effectively in a collaborative team setting.
• Ability to work in a rapidly changing environment with frequent changes in priorities.

Preferred Qualifications-
• Knowledge of immunology and T cell biology as applied to the cell therapy field
• Knowledge or experience with vector and gene editing analytics (AAV, CRISPR, etc)
• Experience with molecular techniques (e.g., qPCR, RT-qPCR, and/or ddPCR).
• Experience with data analysis and interpretation using software (e.g., Softmax Pro, Gen5, Excel, Prism Graphpad).
• Familiarity with statistical analysis and design on experiments (DoE) using JMP software.
• Track record of successful transfer and management of analytical methods
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About Us: Established in 2004, SPECTRAFORCE® is one of the largest and fastest-growing diversity-owned staffing firms in the US. The growth of our company is a direct result of our global client service delivery model that is powered by our state-of-the-art A.I. proprietary talent acquisition platform, robust ISO 9001:2015/ISO 27001 certified processes, and strong and passionate client engaged teams. We have built our business by providing talent and project-based solutions, including Contingent, Permanent, and Statement of Work (SOW) services to over 140 clients in the US, Canada, Puerto Rico, Costa Rica, and India. Key industries that we service include Technology, Financial Services, Life Sciences, Healthcare, Telecom, Retail, Utilities and Transportation. SPECTRAFORCE is built on a concept of “human connection,” defined by our branding attitude of NEWJOBPHORIA®, which is the excitement of bringing joy and freedom to the work lifestyle so our people and clients can reach their highest potential. Learn more at: http://www.spectraforce.com
 
Benefits: SPECTRAFORCE offers ACA compliant health benefits as well as dental, vision, accident, critical illness, voluntary life, and hospital indemnity insurances to eligible employees. Additional benefits offered to eligible employees include commuter benefits, 401K plan with matching, and a referral bonus program. SPECTRAFORCE provides unpaid leave as well as paid sick leave when required by law.

Equal Opportunity Employer: SPECTRAFORCE is an equal opportunity employer and does not discriminate against any employee or applicant for employment because of race, religion, color, sex, national origin, age, sexual orientation, gender identity, genetic information, disability or veteran status, or any other category protected by applicable federal, state, or local laws. Please contact Human Resources at LOA@spectraforce.com if you require reasonable accommodation. 
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position’s starting pay is: $50.00/hr.

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