Position Title : Sr. Associate Scientist or Associate Scientist , RNA Process Development Location : Seattle WA 98109 Duration : 12 Months
Top Skills: - Proficiency with biochemical techniques to analyze oligonucleotides (PAGE and CE) - Proficiency with analytical IP-RP chromatography for RNA (including mRNA) purity - Experience working with, storing, and analyzing purified nucleic acids and proteins - Experience with optimizing molecular cloning reactions - Experience with gene editing primary human cells or immortalized cell-lines
Professional Summary: Seeking a highly motivated Sr. Associate Scientist, or Scientist, to work in a fast-paced PD environment applying rigorous biochemical principles towards developing and characterizing ligated oligonucleotides for gene editing applications. As a part of the Gene Delivery and Editing Process Development (GDEPD) organization, the ideal candidate will possess sufficient experience with handling, manipulating, and characterizing in vitro produced RNA oligomers (50 – 200 nt).
A successful scientist will directly employ molecular cloning, biophysical and analytical tools to develop our next-generation gene edited therapies through the development of RNA oligomers. An outstanding candidate will be driven by a desire to create, optimize, and define processes with speed in a collaborative environment.
Key Responsibilities: • Design and execute nucleic acid ligation reactions using “splint ligation” methodology • Design and execute ion-pairing (IP) reversed-phase (RP) chromatography methods • Perform purification of oligonucleotides using chromatography and/or preparative PAGE • Design and evaluate the performance of new biophysical assays to identify and assess CQA’s • Manage samples and data related to gene editing platform process development • Provide experimental design and executional support to team members in adjacent and related functions (e.g. clinical development programs, high throughput process development, etc.) • Actively participate and support lab maintenance and continuous improvement initiatives • Maintain accurate and detailed laboratory notebook and documentation • Summarize and present data in group meetings and contribute to group discussions • Author technical reports, study memos, and protocols
Basic Qulaifications: • STEM degree with 2+ years of relevant industry experience; title/compensation will be commensurate with education, experience, and skillset • Proficiency with biochemical techniques to analyze oligonucleotides (PAGE and CE) • Proficiency with analytical IP-RP chromatography for RNA (including mRNA) purity • Experience working with, storing, and analyzing purified nucleic acids and proteins • Independently motivated with the ability to work in teams • Ability to communicate clearly and concisely through oral presentation and technical writing • Ability to leverage literature, internal and external resources to solve problems and develop new technologies • Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environment
Preferred Qualifications: • Degree in biological or chemical engineering, biochemistry, or bio-related field • Experience with optimizing molecular cloning reactions • Experience with gene editing primary human cells or immortalized cell-lines • Experience with solid-phase oligonucleotide synthesis • Experience with bioinformatic tools used to predict RNA secondary structure • Experience with JMP for DoE design and analysis
About Us: Established in 2004, SPECTRAFORCE® is one of the largest and fastest-growing diversity-owned staffing firms in the US. The growth of our company is a direct result of our global client service delivery model that is powered by our state-of-the-art A.I. proprietary talent acquisition platform, robust ISO 9001:2015/ISO 27001 certified processes, and strong and passionate client engaged teams. We have built our business by providing talent and project-based solutions, including Contingent, Permanent, and Statement of Work (SOW) services to over 140 clients in the US, Canada, Puerto Rico, Costa Rica, and India. Key industries that we service include Technology, Financial Services, Life Sciences, Healthcare, Telecom, Retail, Utilities and Transportation. SPECTRAFORCE is built on a concept of “human connection,” defined by our branding attitude of NEWJOBPHORIA®, which is the excitement of bringing joy and freedom to the work lifestyle so our people and clients can reach their highest potential. Learn more at: http://www.spectraforce.com
Benefits: SPECTRAFORCE offers ACA compliant health benefits as well as dental, vision, accident, critical illness, voluntary life, and hospital indemnity insurances to eligible employees. Additional benefits offered to eligible employees include commuter benefits, 401K plan with matching, and a referral bonus program. SPECTRAFORCE provides unpaid leave as well as paid sick leave when required by law.
Equal Opportunity Employer: SPECTRAFORCE is an equal opportunity employer and does not discriminate against any employee or applicant for employment because of race, religion, color, sex, national origin, age, sexual orientation, gender identity, genetic information, disability or veteran status, or any other category protected by applicable federal, state, or local laws. Please contact Human Resources at LOA@spectraforce.com if you require reasonable accommodation.
California Applicant Notice: SPECTRAFORCE is committed to complying with the California Privacy Rights Act (“CPRA”) effective January 1, 2023; and all data privacy laws in the jurisdictions in which it recruits and hires employees. A Notice to California Job Applicants Regarding the Collection of Personal Information can be located on our website. Applicants with disabilities may access this notice in an alternative format by contacting NAHR@spectraforce.com.
LA County, CA Applicant Notice: If you are selected for this position with SPECTRAFORCE, your offer is contingent upon the satisfactory completion of several requirements, including but not limited to, a criminal background check. We consider qualified applicants with arrest or conviction records for employment in accordance with all local ordinances and state laws, including the Los Angeles County Fair Chance Ordinance for Employers (FCO) and the California Fair Chance Act (FCA). The background check assessment will consider whether a criminal history could reasonably have a direct, adverse impact on the job-related safety, security, trust, regulatory compliance, or suitability for this role. Such findings may result in withdrawal of a conditional job offer.
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position’s starting pay is: $53.34/hr.
